Medical Treatments for PCOS

Chapter 2

First-Line Medical Treatments

First-line medical treatments for PCOS, following the American Society for Reproductive Medicine guidance, with a note that classifications vary between guidelines. The chapter explains the combined oral contraceptive pill, usually the first choice for irregular periods and for symptoms of excess androgens such as acne and unwanted hair growth. It covers metformin, a diabetes medicine that improves how the body responds to insulin, and eflornithine cream, which slows facial hair growth but does not remove existing hair. For women trying to conceive, it describes clomiphene, which stimulates ovulation and is a first-line fertility treatment.

Chapter 3

Second-Line Medical Treatments

When first-line options do not work or are not suitable, second-line medications may be considered, and this chapter explains them. It notes that some are not specifically licensed for PCOS but are supported by research. Letrozole, originally a breast cancer treatment, is described as an effective way to stimulate ovulation, particularly when clomiphene has not worked. The chapter also covers antiandrogens such as spironolactone, flutamide and finasteride, which block the effects of male hormones to reduce unwanted hair growth. Finally, it discusses anti-obesity medications such as GLP-1 receptor agonists, which are used only alongside lifestyle changes.

Chapter 4

Third-Line Medical Treatment

Third-line treatments are considered when first-line and second-line options have not been effective, and this chapter covers three of them. Inositol, a supplement that acts as an insulin sensitiser and may improve metabolic measures, is discussed with a clear note on where its benefits for ovulation, hair growth and weight remain uncertain. Laparoscopic ovarian drilling is explained as a minor surgical procedure under general anaesthesia for women whose fertility has not improved with medication. The chapter then outlines IVF, from collecting eggs to fertilising them in a laboratory, as a possible next step when medication has not led to pregnancy.

Chapter 5

Health Risks to Monitor Associated with PCOS

PCOS is linked to a higher risk of several other health conditions, and this chapter explains what they are and why monitoring matters. It covers cardiovascular risks such as high blood pressure, unhealthy cholesterol and atherosclerosis, and the raised rates of type 2 diabetes and impaired glucose tolerance. Pregnancy complications, including pre-eclampsia, gestational diabetes and miscarriage, are discussed, along with the slightly higher risk of endometrial hyperplasia and cancer. The chapter also looks at obstructive sleep apnoea, which can occur regardless of body weight, and the depression and anxiety that often go unnoticed.

Chapter 6

Working with Your Doctor

Long-term PCOS care works best with a team, and this final chapter explains who might be involved and what ongoing care looks like. It describes a multidisciplinary approach that can include a gynaecologist, endocrinologist, dermatologist, nutritionist and mental health professional. It stresses regular screening of metabolic and reproductive health, given the higher risk of type 2 diabetes, high cholesterol and high blood pressure, and recommends routine mental health assessments. Monitoring weight and habits such as diet and physical activity is covered too. The module closes by drawing together the medications and strategies discussed earlier.